Statins Help Decrease Vein Blood Clot Risk In Women Taking Hormone Therapy Statins Help Decrease Vein Blood Clot Risk In Women Taking Hormone Therapy

Statins Help Decrease Vein Blood Clot Risk In Women Taking Hormone Therapy

  • Hormone therapy is used to ease menopausal symptoms such as hot flashes.

  • However, it comes with certain risks, including a higher chance of developing blood clots.

  • Researchers at the University of Texas Medical Branch have discovered that including statin therapy can reduce the risk of venous thromboembolism in women who are undergoing menopausal hormone therapy.

Hormone therapy is an option for postmenopausal women to ease uncomfortable symptoms like hot flashes.

However, there are potential heart-related risks associated with menopausal hormone therapy, including an increased risk of stroke when it's initiated later in menopause and a higher chance of developing blood clots.

A recent study conducted by researchers at the University of Texas Medical Branch has shown that using statin therapy may help reduce the risk of venous thromboembolism (VTE) or deep vein thromboembolism (DVT) in women who are undergoing menopausal hormone therapy. This condition occurs when blood clots form in the veins.

The study's findings were published in the journal JAMA Network Open.

Can Hormone Therapy Cause Blood Clots?

A study conducted by researchers in the field of women's health and hormone therapy has shed light on the risks associated with estrogen therapy for menopausal symptoms. The Women's Health Initiative, a study conducted two decades ago, initially raised concerns about the use of estrogen therapy, as it found an increased risk of venous thromboembolism—a potentially life-threatening condition where clots can form in the arms or legs and travel to the lungs—among women using oral conjugated equine estrogen, with or without progestin.

In a previous study, researchers discovered that transdermal estrogen, such as the estradiol patch, did not carry the same elevated risk of venous thromboembolism as oral forms of estrogen. However, they also observed that women between the ages of 50 and 64 who were taking oral contraceptives, whether for menopause symptoms or birth control, faced a threefold higher risk of venous thromboembolism compared to those on menopausal hormone therapy.

These findings have had an impact on clinical practice, with many healthcare providers being cautious about prescribing estrogen therapy to menopausal women due to concerns about clotting risks. The goal has been to identify safer hormonal options for managing menopausal symptoms.

In light of these concerns, the researchers sought to explore whether statin therapy, commonly used for managing cholesterol levels and reducing cardiovascular risk, might mitigate the increased risk of venous thromboembolism associated with hormone therapy. Previous research has indicated that statins can reduce the risk of venous thromboembolism and major vascular events. Thus, the study aimed to investigate whether combining statin therapy with hormone therapy could potentially reduce the risk of venous thromboembolism in menopausal women.

In summary, this study contributes to our understanding of the risks associated with hormone therapy for menopausal symptoms. It explores the potential of statin therapy to mitigate these risks, providing valuable insights for healthcare practitioners and menopausal women seeking safe and effective treatment options.

Hormone-Statin Therapy Decreases Blood Clot Risk.

In a recent observational study, researchers examined data from nearly 224,000 women aged 50 to 64 from 2007 to 2019.

Among the study participants, approximately 20,000 had been exposed to hormone therapy recently, while about 36,000 were currently using statin therapy.

When they analysed the data, scientists discovered that women who had recently undergone hormone therapy without current statin therapy had a 53% higher risk of venous thromboembolism.

However, women who had been exposed to both hormonal therapy and current statin therapy had their venous thromboembolism risk reduced to only 25%.

It's important to know that some forms of estrogen can make your blood clot more easily. This means you might be at a higher risk of getting blood clots. On the other hand, statins, a type of medication, lower the chance of getting blood clots in your veins, but we're not entirely sure how they do it. Some scientific studies suggest that statins reduce inflammation in your body.

It's important to highlight that statins are generally well-tolerated, commonly prescribed for cardiovascular disease, and can lower the risk of major vascular events.

What Are The Benefits And Risks Of Statin-Hormone Therapy?

Based on the findings of this study, if a patient requires statin therapy for medical reasons, it doesn't necessarily mean that hormonal therapy cannot be considered. Moreover, initiating hormonal therapy during the early perimenopausal years may carry lower risks compared to starting it later.

It's important to note that this study's observed risk of venous thromboembolism was lower than in large clinical trials conducted two decades ago. The differences in risk could be attributed to factors like the method of estrogen exposure (oral), the specific type of estrogen used (conjugated equine estrogen), and the fact that most women in those trials began hormonal therapy after age 60.

However, it's crucial to remember that there is a potential risk of breast cancer associated with hormone therapy, and statins have not been shown to reduce this risk.

Healthcare providers are encouraged to carefully consider whether hormone therapy is appropriate for their patients, taking into account factors such as the choice of estrogen type, the method of administration, and the potential use of statin therapy. While there may still be some risk of venous thromboembolism with menopausal hormone therapy, this risk might be acceptable to patients and clinicians when weighed against the discomfort of experiencing menopausal symptoms like hot flashes. Notably, high-intensity statins seem to reduce the risk of venous thromboembolism by approximately 30% in women undergoing hormone therapy.

Statins Offer A Preventive Option For Vein Blood Clots

Some experts who were not part of a recent study shared their thoughts. They mentioned that hormone therapy can slightly increase the risk of blood clots, which is usually not a big problem for most people but can sometimes lead to severe


To tackle this risk, researchers are looking into statin drugs known to reduce clot formation in blood vessels. Statins do this by reducing inflammation and preventing clotting factors from sticking to the walls of blood vessels. This suggests that statins help lower the risk of a type of blood clot called venous thrombosis.

In the following stages of research, scientists might study women who are taking hormone therapy, especially those who don't usually take statins. They would randomly give some of these women statin drugs and others no statins to see if statins can indeed lower the risk of venous thrombosis in women who wouldn't typically be prescribed statins for heart problems.

Please contact Mobi Doctor for professional healthcare support if you require medical assistance. Your well-being is our priority.


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