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Amoxicillin-Trihydrat shortage — availability across Europe

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MEDICALLY REVIEWED
Dr. Chrysoula I. Liakou MD, PhD
Internal Medicine Specialist
Cancer Immunology Researcher
Reviewed 30 July 2026 · next review due 30 January 2027

Amoxicillin-Trihydrat currently has availability issues reported in 3 European registers: Germany, Spain, Italy.

Shortage  ATC J01CA04 · also listed as: Amoxicillin-Trihydrat · AMOXICILINA · AMOXICILLINA · data refreshed 21 September 2026

Key facts

As of 21 September 2026, 3 of the 8 tracked registers list current availability issues for Amoxicillin-Trihydrat, covering 6 affected product presentations. The longest-running open report was filed in Italy on 2024-01-15 and has now been open for about 32 months. Where agencies state a cause, unexpectedly high demand lead with 2 of the 4 stated-cause reports, followed by commercial decisions or discontinuation with 2. The furthest expected-resolution date currently on file is 2026-12-31; the earliest is 2026-09-29. Momentum is current, not historical: 3 of the open reports were filed within the last 90 days. The issue spread across registers over time rather than at once: Italy reported first (2024-01-15), with Spain following roughly 30 months later — a pattern typical of supply problems cascading between national markets. Registers in Germany, Spain, Italy indicate that alternatives or equivalents are available — a pharmacist or doctor can advise on switching. In the WHO ATC classification, Amoxicillin-Trihydrat is coded J01CA04 — a medicine acting on anti-infectives for systemic use — so clinically related products appear under “Related medicines” below.

WhereStatus & productsSinceExpected end Reason / alternativesSource
🇩🇪 GermanyShortage
Amoxicillin AL TS
2024-05-012026-12-01Erhöhte Nachfrage
Alternatives: N/A
register ↗
🇪🇸 SpainShortage
AMOXICILINA / ACIDO CLAVULANICO SANDOZ 250 mg/62,5 mg/5 ml POLVO PARA SUSPENSION ORAL EFG, 1 frasco de 120 ml
+ 1 more products
AMOXICILINA/ACIDO CLAVULANICO SANDOZ 2000mg/200mg POLVO PARA SOLUCION PARA PERFUSION EFG, 10 viales
2026-07-122026-10-25Existen otros medicamentos con los mismos principios activos y misma vía.
Alternatives: Existe/n otro/s medicamento/s con los mismos principios activos y para la misma vía de administración.
register ↗
🇮🇹 ItalyShortage
AMOSOL
+ 2 more products
AMOXICILLINA GIT
AMOXICILLINA SODICA K24 PHARMACEUTICALS
2024-01-152026-12-31Elevata richiesta
Alternatives: AIFA: equivalents with the same active substance are available.
register ↗

New register reports per month

2024-01: 12024-02: 02024-03: 12024-04: 02024-05: 12024-06: 02024-07: 02024-08: 02024-09: 02024-10: 02024-11: 02024-12: 02025-01: 02025-02: 02025-03: 02025-04: 02025-05: 02025-06: 02025-07: 02025-08: 02025-09: 02025-10: 02025-11: 02025-12: 02026-01: 02026-02: 02026-03: 02026-04: 02026-05: 02026-06: 02026-07: 12026-08: 02026-09: 22024-012026-09

Full report history (6 register entries)

Every individual register entry for Amoxicillin-Trihydrat in the tracked sources, newest first — including resolved and discontinued reports.

Reg.ProductStatusReportedExpected endStated reason
🇮🇹 ITAMOXICILLINA SODICA K24 PHARMACEUTICALSShortage2026-09-14Cessata commercializzazione temporanea
🇪🇸 ESAMOXICILINA/ACIDO CLAVULANICO SANDOZ 2000mg/200mg POLVO PARA SOLUCION Shortage2026-09-132026-10-25Existen otros medicamentos con los mismos principios activos
🇪🇸 ESAMOXICILINA / ACIDO CLAVULANICO SANDOZ 250 mg/62,5 mg/5 ml POLVO PARA Shortage2026-07-122026-09-29Existen otros medicamentos con los mismos principios activos
🇩🇪 DEAmoxicillin AL TSShortage2024-05-012026-12-01Erhöhte Nachfrage
🇮🇹 ITAMOXICILLINA GITShortage2024-03-012026-12-31Cessata commercializzazione temporanea
🇮🇹 ITAMOSOLShortage2024-01-15Elevata richiesta

Frequently asked

Is Amoxicillin-Trihydrat currently in shortage in Europe?

Yes. As of 21 September 2026, availability issues are reported in: Germany, Spain, Italy. Availability is national — a shortage in one country does not mean it is short everywhere.

When is the Amoxicillin-Trihydrat shortage expected to end?

Agency prognoses on file range from 2026-09-29 to 2026-12-31. These are manufacturer-reported estimates and frequently move; check the linked register entry for the latest date.

Are there alternatives to Amoxicillin-Trihydrat?

6 of the active register entries indicate alternatives or equivalents (same active substance or an alternative treatment). Do not switch on your own — a pharmacist or prescriber can confirm the right substitute in your country.

Where does this Amoxicillin-Trihydrat availability data come from?

Directly from the official medicines-agency registers that list Amoxicillin-Trihydrat: BfArM (Germany), AEMPS CIMA (Spain), AIFA (Italy). Every row on this page links to the underlying official record, and the dataset is refreshed from the primary sources every morning. Cross-language matching groups the same active substance across registers, so national spellings all resolve to this page.

Related medicines (same ATC class)

Embed this tracker

Pharmacies, patient sites and newsrooms are welcome to embed the live status of Amoxicillin-Trihydrat — free, with attribution. Copy this snippet:

<iframe src="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/amoxicillin-trihydrat/embed.html" width="100%" height="150" loading="lazy" style="border:1px solid #e1e0d9;border-radius:12px" title="Amoxicillin-Trihydrat availability in Europe"></iframe>
<p style="font-size:12px">Source: <a href="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/amoxicillin-trihydrat/">Amoxicillin-Trihydrat shortage status — European Medicine Shortage Tracker</a> by MobiDoctor</p>
Cite: “Amoxicillin-Trihydrat: availability status across 3 European registers — European Medicine Shortage Tracker (MobiDoctor), 21 September 2026.” Link this page and the agency record. Statuses come from the linked official registers and can change daily.