Sildenafil May Help Reduce Alzheimer's Risk

●     Recent research suggests that sildenafil, which is a critical component in medications for erectile dysfunction and certain forms of hypertension, might also have the potential to fend off and treat Alzheimer's disease.

●     Research findings show that individuals who are already on a sildenafil regimen, famously known as the active ingredient in Viagra, showed a notably lower occurrence of Alzheimer's compared to those who aren't taking it.

●     However, it's worth noting a word of caution from at least one specialist who points out that such observational studies might not provide the whole picture, urging people to interpret these results sceptically.

Sildenafil, which you might know as the central part of Viagra, is also used in a medicine called Revatio for pulmonary arterial hypertension. There's exciting news that this same ingredient might also help fight Alzheimer's disease.

A study found that individuals using sildenafil to address erectile dysfunction or pulmonary arterial hypertension experienced a significant decrease in Alzheimer's disease occurrence, ranging between 30% to 54% when compared to those not on the medication.

Sildenafil Lowers Tau Levels In The Brain

Alzheimer's disease is the most common kind of memory loss condition called dementia. Right now, around 9.7 million Europeans are living with Alzheimer's, making it a major cause of death. What's more, as more people get older, the number of folks with Alzheimer's is expected to go up.

While deaths from things like strokes, heart problems, and HIV have gone down from 2000 to 2019, deaths from Alzheimer's have shot up by more than 145%. That's a huge increase.

Alzheimer's gets worse over time. It usually starts with forgetting stuff and can end up with serious problems, like having trouble talking to people or understanding what's happening around you.

In this new study, researchers used computer programs to look at the health records of millions of people. They found that in one database, people taking sildenafil (the stuff in Viagra) had a 54% lower chance of getting Alzheimer's. In another database, the risk was reduced by 30%.

After seeing these numbers, the scientists did more experiments in the lab. They discovered that sildenafil could lower harmful tau proteins in the brain, which are a big problem in Alzheimer's. These proteins, along with another culprit called amyloid plaques, are thought to cause the disease. Even though recent studies have questioned the role of amyloid plaques, the harmful proteins still seem to play a big part.

They also observed that neurons exposed to sildenafil promoted improved brain function cell growth and reduced inflammation and metabolic processes associated with the cognitive degeneration that occurs with Alzheimer's.

PDE 5 Inhibitors To Treat Alzheimer’s?

Sildenafil, the medicine commonly used for erectile dysfunction, works by blocking a specific enzyme in the body. There's been some buzz about whether this type of medicine could also help prevent Alzheimer's disease. However, experts caution that there's no solid proof yet that it can treat Alzheimer's.

A big study from the UK hinted that these medicines might lower the risk of getting Alzheimer's, but it's not clear if they can treat the disease itself. Since the study was based on health records, it couldn't definitively say whether there was a real connection.

Before jumping to any conclusions, more research and specially designed studies are needed. These studies should include a wide range of people, including women, to determine whether these medicines could make a difference in treating Alzheimer's.

One challenge with the study was that it didn't diagnose Alzheimer's with the most thorough tests, like brain scans or checks after someone has passed away.

Some think that if sildenafil does help with Alzheimer's, it might be because it boosts certain pathways in the body and improves blood flow. These pathways are involved in many cell functions and are looked at in cancer research, which might give clues about Alzheimer's.

But remember, all of this is still being explored, and it's too soon to say for sure if these medicines could be a new treatment for Alzheimer's.

Safety Concerns About Repurposing Drugs

Finding sildenafil's potential use for Alzheimer's shows how computer searches can uncover new uses for existing drugs. This approach has already led to discoveries like gemfibrozil for cholesterol, astaxanthin as an antioxidant, and minocycline for bacterial infections.

This method of drug repurposing is exciting because it takes advantage of drugs that are already approved and well-understood in terms of safety and side effects. This can make the process of finding new treatments faster and cheaper.

However, tackling Alzheimer's disease is tricky because it's a very complex condition. It might require a mix of different treatments to combat it effectively.

When thinking about using an existing drug for Alzheimer's, it's important to test it thoroughly again, especially in older populations that represent the diversity of people with the disease.

The Alzheimer's Association funds numerous clinical trials through its Part The Cloud initiative, investing over $68 million in 65 trials. These trials explore various angles of the disease, including new and repurposed treatments.

The trials are looking into different ways to tackle the disease, such as understanding how the immune system impacts brain changes related to Alzheimer's, how brain cells use energy, how they get rid of waste, and how blood flow in the brain works.

Regarding sildenafil, it's crucial not to rush into using prescription medications or over-the-counter products similar to it with the hope of preventing Alzheimer's or other dementias based on early research findings.

Talking to a doctor before starting or changing any medication is always best.

If you need medical guidance or support related to Alzheimer's, don't hesitate to get in touch with Mobi Doctor. They're ready to assist you with your concerns.