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Tacrolimus currently has availability issues reported in 3 European registers: Germany, Spain, Italy.
Shortage ATC L04AD02 · also listed as: Tacrolimus-Monohydrat · Tacrolimus · data refreshed 4 October 2026
As of 4 October 2026, 3 of the 10 tracked registers list current availability issues for Tacrolimus, covering 12 affected product presentations. The longest-running open report was filed in Germany on 2025-02-15 and has now been open for about 20 months. Where agencies state a cause, unexpectedly high demand lead with 5 of the 7 stated-cause reports, followed by manufacturing problems with 2. The furthest expected-resolution date currently on file is 2026-12-31; the earliest is 2026-10-08. Momentum is current, not historical: 2 of the open reports were filed within the last 90 days. The issue spread across registers over time rather than at once: Germany reported first (2025-02-15), with Italy following roughly 17 months later — a pattern typical of supply problems cascading between national markets. Registers in Germany, Spain, Italy indicate that alternatives or equivalents are available — a pharmacist or doctor can advise on switching. In the WHO ATC classification, Tacrolimus is coded L04AD02 — a medicine acting on antineoplastic and immunomodulating agents — so clinically related products appear under “Related medicines” below.
| Where | Status & products | Since | Expected end | Reason / alternatives | Source |
|---|---|---|---|---|---|
| 🇩🇪 Germany | Shortage Tacpan 5 mg Hartkapseln + 6 more productsTacrolimus AL 0,5 mg Hartkapseln, retardiert Tacrolimus AL 1 mg Hartkapseln, retardiert Tacrolimus AL 3 mg Hartkapseln, retardiert Tacrolimus AL 5 mg Hartkapseln Tacrolimus AL 5 mg Hartkapseln, retardiert Takrozem 1 mg/g Salbe | 2025-02-15 | 2026-12-31 | Sonstige Alternatives: Prograf 5mg Hartkapseln - Einreichungsnummer: 2138355 | register ↗ |
| 🇪🇸 Spain | Shortage TACROLIMUS STADAFARMA 0,5 MG CAPSULAS DURAS DE LIBERACION PROLONGADA EFG, 30 cápsulas + 3 more productsTACROLIMUS STADAFARMA 1 MG CAPSULAS DURAS DE LIBERACION PROLONGADA EFG, 60 cápsulas TACROLIMUS STADAFARMA 3 MG CAPSULAS DURAS DE LIBERACION PROLONGADA EFG, 30 cápsulas TACROLIMUS STADAFARMA 5 MG CAPSULAS DURAS DE LIBERACION PROLONGADA EFG, 30 cápsulas | 2025-03-12 | — | Existen otros medicamentos con el mismo principio activo y misma vía. Alternatives: Existe/n otro/s medicamento/s con el mismo principio activo y para la misma vía de administración. | register ↗ |
| 🇮🇹 Italy | Shortage ADOPORT | 2026-07-20 | — | Problemi produttivi Alternatives: AIFA: equivalents with the same active substance are available. | register ↗ |
Every individual register entry for Tacrolimus in the tracked sources, newest first — including resolved and discontinued reports.
| Reg. | Product | Status | Reported | Expected end | Stated reason |
|---|---|---|---|---|---|
| 🇩🇪 DE | Tacrolimus AL 5 mg Hartkapseln | Shortage | 2026-09-02 | 2026-10-08 | Erhöhte Nachfrage |
| 🇮🇹 IT | ADOPORT | Shortage | 2026-07-20 | — | Problemi produttivi |
| 🇩🇪 DE | Tacpan 5 mg Hartkapseln | Shortage | 2026-02-01 | 2026-10-31 | Sonstige |
| 🇩🇪 DE | Takrozem 1 mg/g Salbe | Shortage | 2026-01-27 | 2026-12-31 | Unzureichende Produktionskapazitäten |
| 🇪🇸 ES | TACROLIMUS STADAFARMA 0,5 MG CAPSULAS DURAS DE LIBERACION PROLONGADA E | Shortage | 2025-03-12 | — | Existen otros medicamentos con el mismo principio activo y m |
| 🇪🇸 ES | TACROLIMUS STADAFARMA 1 MG CAPSULAS DURAS DE LIBERACION PROLONGADA EFG | Shortage | 2025-03-12 | — | Existen otros medicamentos con el mismo principio activo y m |
| 🇪🇸 ES | TACROLIMUS STADAFARMA 3 MG CAPSULAS DURAS DE LIBERACION PROLONGADA EFG | Shortage | 2025-03-12 | — | Existen otros medicamentos con el mismo principio activo y m |
| 🇪🇸 ES | TACROLIMUS STADAFARMA 5 MG CAPSULAS DURAS DE LIBERACION PROLONGADA EFG | Shortage | 2025-03-12 | — | Existen otros medicamentos con el mismo principio activo y m |
| 🇩🇪 DE | Tacrolimus AL 0,5 mg Hartkapseln, retardiert | Shortage | 2025-02-15 | 2026-12-31 | Erhöhte Nachfrage |
| 🇩🇪 DE | Tacrolimus AL 1 mg Hartkapseln, retardiert | Shortage | 2025-02-15 | 2026-12-31 | Erhöhte Nachfrage |
| 🇩🇪 DE | Tacrolimus AL 3 mg Hartkapseln, retardiert | Shortage | 2025-02-15 | 2026-12-31 | Erhöhte Nachfrage |
| 🇩🇪 DE | Tacrolimus AL 5 mg Hartkapseln, retardiert | Shortage | 2025-02-15 | 2026-12-31 | Erhöhte Nachfrage |
Yes. As of 4 October 2026, availability issues are reported in: Germany, Spain, Italy. Availability is national — a shortage in one country does not mean it is short everywhere.
Agency prognoses on file range from 2026-10-08 to 2026-12-31. These are manufacturer-reported estimates and frequently move; check the linked register entry for the latest date.
12 of the active register entries indicate alternatives or equivalents (same active substance or an alternative treatment). Do not switch on your own — a pharmacist or prescriber can confirm the right substitute in your country.
Directly from the official medicines-agency registers that list Tacrolimus: BfArM (Germany), AEMPS CIMA (Spain), AIFA (Italy). Every row on this page links to the underlying official record, and the dataset is refreshed from the primary sources every morning. Cross-language matching groups the same active substance across registers, so national spellings all resolve to this page.
Pharmacies, patient sites and newsrooms are welcome to embed the live status of Tacrolimus — free, with attribution. Copy this snippet:
<iframe src="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/tacrolimus/embed.html" width="100%" height="150" loading="lazy" style="border:1px solid #e1e0d9;border-radius:12px" title="Tacrolimus availability in Europe"></iframe> <p style="font-size:12px">Source: <a href="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/tacrolimus/">Tacrolimus shortage status — European Medicine Shortage Tracker</a> by MobiDoctor</p>