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Topotecan currently has availability issues reported in 4 European registers: Austria, Greece, Ireland, Sweden.
Shortage ATC L01XX17 · also listed as: TOPOTECAN HYDROCHLORID · topotecan · Topotecan hydrochloride · topotekanhydroklorid · data refreshed 14 September 2026
As of 14 September 2026, 4 of the 9 tracked registers list current availability issues for Topotecan, covering 4 affected product presentations. The longest-running open report was filed in Austria on 2024-08-21 and has now been open for about 25 months. Where agencies state a cause, quality issues lead with 1 of the 1 stated-cause reports. The furthest expected-resolution date currently on file is 2027-02-08; the earliest is 2027-02-08. Notably, 1 report has already passed the expected-resolution date without closing — prognoses for this medicine should be read as estimates, not commitments. The issue spread across registers over time rather than at once: Austria reported first (2024-08-21), with Ireland following roughly 23 months later — a pattern typical of supply problems cascading between national markets. Registers in Greece, Ireland, Sweden indicate that alternatives or equivalents are available — a pharmacist or doctor can advise on switching. In the WHO ATC classification, Topotecan is coded L01XX17 — a medicine acting on antineoplastic and immunomodulating agents — so clinically related products appear under “Related medicines” below.
| Where | Status & products | Since | Expected end | Reason / alternatives | Source |
|---|---|---|---|---|---|
| 🇪🇺 EU-wide (EMA) | Resolved Hycamtin (topotecan) | 2023-11-07 | — | Ovarian Neoplasms;Uterine Cervical Neoplasms;Small Cell Lung Carcinoma Alternatives: EMA lists available alternatives — see the EMA record. | register ↗ |
| 🇦🇹 Austria | Shortage HYCAMTIN 4 mg Pulver zur Herstellung eines Infusionslösungskonzentrats | 2024-08-21 | — | — | register ↗ |
| 🇬🇷 Greece | Limited availability Topotecan | 2026-02-18 | 2027-02-08 | ΑΡΗΤΗ A.E. διαδικασία Εναλλακτικά μέσω έκτακτης εισαγωγής Alternatives: LEUPROL PS.INJ.SUS 11,25MG/VIAL ΚΙΤ ΠΟΥ ΠΕΡΙΈΧΕΙ: Εναλλακτικά άλλα σκευάσματα της ίδιας δρ | register ↗ |
| 🇮🇪 Ireland | Shortage HYCAMTIN 0.25 mg hard capsules EU/1/96/027/006 Sandoz Pharmaceuticals d. | 2026-07-20 | — | Quality issue (Multiple countries) Alternatives: Alternative(s) available — see the national register. | register ↗ |
| 🇸🇪 Sweden | Shortage Topotecan Ebewe 1 mg/ml Koncentrat till infusionsvätska, lösning | 2026-06-08 | 2026-08-14 | — Alternatives: Alternative(s) available — see the national register. | register ↗ |
Every individual register entry for Topotecan in the tracked sources, newest first — including resolved and discontinued reports.
| Reg. | Product | Status | Reported | Expected end | Stated reason |
|---|---|---|---|---|---|
| 🇮🇪 IE | HYCAMTIN 0.25 mg hard capsules EU/1/96/027/006 Sandoz Pharmaceuticals | Shortage | 2026-07-20 | — | Quality issue (Multiple countries) |
| 🇸🇪 SE | Topotecan Ebewe 1 mg/ml Koncentrat till infusionsvätska, lösning | Shortage | 2026-06-08 | 2026-08-14 | |
| 🇬🇷 GR | Topotecan | Limited availability | 2026-02-18 | 2027-02-08 | ΑΡΗΤΗ A.E. διαδικασία Εναλλακτικά μέσω έκτακτης εισαγωγής |
| 🇦🇹 AT | HYCAMTIN 4 mg Pulver zur Herstellung eines Infusionslösungskonzentrats | Shortage | 2024-08-21 | — | |
| 🇪🇺 EU | Hycamtin (topotecan) | Resolved | 2023-11-07 | — | Ovarian Neoplasms;Uterine Cervical Neoplasms;Small Cell Lung |
Yes. As of 14 September 2026, availability issues are reported in: Austria, Greece, Ireland, Sweden. Availability is national — a shortage in one country does not mean it is short everywhere.
Agency prognoses on file range from 2027-02-08 to 2027-02-08. These are manufacturer-reported estimates and frequently move; check the linked register entry for the latest date.
3 of the active register entries indicate alternatives or equivalents (same active substance or an alternative treatment). Do not switch on your own — a pharmacist or prescriber can confirm the right substitute in your country.
Directly from the official medicines-agency registers that list Topotecan: BASG (Austria), EMA shortages catalogue (EU), EOF limited-availability list (Greece), HPRA (Ireland), Läkemedelsverket (Sweden). Every row on this page links to the underlying official record, and the dataset is refreshed from the primary sources every morning. Cross-language matching groups the same active substance across registers, so national spellings all resolve to this page.
Pharmacies, patient sites and newsrooms are welcome to embed the live status of Topotecan — free, with attribution. Copy this snippet:
<iframe src="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/topotecan/embed.html" width="100%" height="150" loading="lazy" style="border:1px solid #e1e0d9;border-radius:12px" title="Topotecan availability in Europe"></iframe> <p style="font-size:12px">Source: <a href="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/topotecan/">Topotecan shortage status — European Medicine Shortage Tracker</a> by MobiDoctor</p>