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Mannitol shortage — availability across Europe

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MEDICALLY REVIEWED
Dr. Chrysoula I. Liakou MD, PhD
Internal Medicine Specialist
Cancer Immunology Researcher
Reviewed 30 July 2026 · next review due 30 January 2027

Mannitol currently has availability issues reported in 5 European registers: Spain, EU-wide, Ireland, Italy, Sweden.

Shortage  ATC — · also listed as: MANITOL · mannitol · MANNITOLO · data refreshed 8 September 2026

Key facts

As of 8 September 2026, 5 of the 9 tracked registers list current availability issues for Mannitol, covering 12 affected product presentations. The longest-running open report was filed in Ireland on 2024-10-31 and has now been open for about 23 months. Where agencies state a cause, manufacturing problems lead with 4 of the 6 stated-cause reports, followed by commercial decisions or discontinuation with 2. The furthest expected-resolution date currently on file is 2026-11-30; the earliest is 2026-11-30. Notably, 1 report has already passed the expected-resolution date without closing — prognoses for this medicine should be read as estimates, not commitments. Momentum is current, not historical: 2 of the open reports were filed within the last 90 days. The issue spread across registers over time rather than at once: Ireland reported first (2024-10-31), with the EMA catalogue following roughly 13 months later — a pattern typical of supply problems cascading between national markets. Registers in Spain, EU-wide, Ireland, Italy, Sweden indicate that alternatives or equivalents are available — a pharmacist or doctor can advise on switching.

Shortage Listed in the EMA shortages catalogue — EU-level issue. EMA lists available alternatives — see the EMA record. EMA record ↗
WhereStatus & productsSinceExpected end Reason / alternativesSource
🇪🇺 EU-wide (EMA)Shortage
Bronchitol (mannitol)
2025-11-14
Alternatives: EMA lists available alternatives — see the EMA record.
register ↗
🇪🇸 SpainShortage
MANITOL MEIN 10% solución para perfusión, 12 frascos de 250 ml
+ 3 more products
MANITOL MEIN 10% solución para perfusión, 12 frascos de 500 ml
MANITOL MEIN 20% solución para perfusión, 12 frascos de 250 ml
MANITOL MEIN 20% solución para perfusión, 12 frascos de 500 ml
2025-01-19Existen otros medicamentos con el mismo principio activo y misma vía.
Alternatives: Existe/n otro/s medicamento/s con el mismo principio activo y para la misma vía de administración.
register ↗
🇮🇪 IrelandShortage
Bronchitol 40 mg inhalation powder, hard capsules EU/1/12/760/001-002 Ph
+ 1 more products
Osmohale, inhalation powder, hard capsule
2024-10-312026-11-30Manufacturing delay (Multiple countries)
Alternatives: Alternative(s) available — see the national register.
register ↗
🇮🇹 ItalyShortage
BRONCHITOL
+ 3 more products
BRONCHITOL
MANNITOLO FKI
MANNITOLO FKI
2024-11-012026-11-30Problemi produttivi
Alternatives: AIFA: import of a foreign equivalent can be authorised.
register ↗
🇸🇪 SwedenShortage
Aridol Inhalationspulver, hård kapsel
2025-10-152026-06-15
Alternatives: Alternative(s) available — see the national register.
register ↗

New register reports per month

2024-10: 12024-11: 12024-12: 02025-01: 12025-02: 02025-03: 02025-04: 12025-05: 02025-06: 02025-07: 22025-08: 02025-09: 02025-10: 22025-11: 12025-12: 02026-01: 02026-02: 02026-03: 02026-04: 02026-05: 12024-102026-05

Full report history (12 register entries)

Every individual register entry for Mannitol in the tracked sources, newest first — including resolved and discontinued reports.

Reg.ProductStatusReportedExpected endStated reason
🇮🇹 ITMANNITOLO FKIShortage2026-12-15Cessata commercializzazione definitiva
🇮🇹 ITMANNITOLO FKIShortage2026-11-07Cessata commercializzazione definitiva
🇮🇹 ITBRONCHITOLShortage2026-05-15Problemi produttivi
🇪🇺 EUBronchitol (mannitol)Shortage2025-11-14
🇪🇸 ESMANITOL MEIN 20% solución para perfusión, 12 frascos de 500 mlShortage2025-10-29Existen otros medicamentos con el mismo principio activo y m
🇸🇪 SEAridol Inhalationspulver, hård kapselShortage2025-10-152026-06-15
🇮🇪 IEOsmohale, inhalation powder, hard capsuleShortage2025-07-152026-11-30Manufacturing delay (Global)
🇪🇸 ESMANITOL MEIN 10% solución para perfusión, 12 frascos de 500 mlShortage2025-07-07Existen otros medicamentos con el mismo principio activo y m
🇪🇸 ESMANITOL MEIN 20% solución para perfusión, 12 frascos de 250 mlShortage2025-04-08Existen otros medicamentos con el mismo principio activo y m
🇪🇸 ESMANITOL MEIN 10% solución para perfusión, 12 frascos de 250 mlShortage2025-01-19Existen otros medicamentos con el mismo principio activo y m
🇮🇹 ITBRONCHITOLShortage2024-11-012026-11-30Problemi produttivi
🇮🇪 IEBronchitol 40 mg inhalation powder, hard capsules EU/1/12/760/001-002 Shortage2024-10-312026-11-30Manufacturing delay (Multiple countries)

Frequently asked

Is Mannitol currently in shortage in Europe?

Yes. As of 8 September 2026, availability issues are reported in: Spain, EU-wide (EMA), Ireland, Italy, Sweden. Availability is national — a shortage in one country does not mean it is short everywhere.

When is the Mannitol shortage expected to end?

Agency prognoses on file range from 2026-11-30 to 2026-11-30. These are manufacturer-reported estimates and frequently move; check the linked register entry for the latest date.

Are there alternatives to Mannitol?

12 of the active register entries indicate alternatives or equivalents (same active substance or an alternative treatment). Do not switch on your own — a pharmacist or prescriber can confirm the right substitute in your country.

Where does this Mannitol availability data come from?

Directly from the official medicines-agency registers that list Mannitol: AEMPS CIMA (Spain), EMA shortages catalogue (EU), HPRA (Ireland), AIFA (Italy), Läkemedelsverket (Sweden). Every row on this page links to the underlying official record, and the dataset is refreshed from the primary sources every morning. Cross-language matching groups the same active substance across registers, so national spellings all resolve to this page.

Embed this tracker

Pharmacies, patient sites and newsrooms are welcome to embed the live status of Mannitol — free, with attribution. Copy this snippet:

<iframe src="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/mannitol/embed.html" width="100%" height="150" loading="lazy" style="border:1px solid #e1e0d9;border-radius:12px" title="Mannitol availability in Europe"></iframe>
<p style="font-size:12px">Source: <a href="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/mannitol/">Mannitol shortage status — European Medicine Shortage Tracker</a> by MobiDoctor</p>
Cite: “Mannitol: availability status across 5 European registers — European Medicine Shortage Tracker (MobiDoctor), 8 September 2026.” Link this page and the agency record. Statuses come from the linked official registers and can change daily.