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Ifosfamide currently has availability issues reported in 7 European registers: Austria, Germany, EU-wide, France, Ireland, Italy, Sweden.
Shortage ATC L01AA06 · also listed as: IFOSFAMID · ifosfamide · data refreshed 8 September 2026
As of 8 September 2026, 7 of the 9 tracked registers list current availability issues for Ifosfamide, covering 13 affected product presentations. The longest-running open report was filed in Italy on 2025-12-16 and has now been open for about 9 months. Where agencies state a cause, manufacturing problems lead with 8 of the 9 stated-cause reports, followed by active-ingredient (API) supply issues with 1. The furthest expected-resolution date currently on file is 2027-12-31; the earliest is 2026-12-31. Notably, 2 reports have already passed the expected-resolution date without closing — prognoses for this medicine should be read as estimates, not commitments. Momentum is current, not historical: 4 of the open reports were filed within the last 90 days. Registers in Germany, Ireland, Italy, Sweden indicate that alternatives or equivalents are available — a pharmacist or doctor can advise on switching. In the WHO ATC classification, Ifosfamide is coded L01AA06 — a medicine acting on antineoplastic and immunomodulating agents — so clinically related products appear under “Related medicines” below.
| Where | Status & products | Since | Expected end | Reason / alternatives | Source |
|---|---|---|---|---|---|
| 🇪🇺 EU-wide (EMA) | Shortage Ifosfamide | 2026-02-12 | — | Cancer | register ↗ |
| 🇦🇹 Austria | Limited availability Holoxan 1 g - Trockensubstanz zur Injektionsbereitung + 1 more productsHoloxan 2 g - Trockensubstanz zur Injektionsbereitung | 2026-01-26 | — | — | register ↗ |
| 🇩🇪 Germany | Shortage Holoxan + 4 more productsIFO-cell 2g Konzentrat zur Herstellung einer Infusionslösung IFO-cell 5 g Konzentrat zur Herstellung einer Infusionslösung IFO-cell N 1000 IFO-cell N 2000 | 2026-01-21 | 2027-12-31 | Probleme in der Herstellung Alternatives: N/A | register ↗ |
| 🇫🇷 France | Limited availability Holoxan 1000 mg, poudre pour solution injectable et 2000 mg, poudre pour usage parentéral | — | — | Hématologie, Oncologie/Radiothérapie | register ↗ |
| 🇮🇪 Ireland | Shortage Mitoxana 1 g Powder for Sterile Concentrate + 1 more productsMitoxana 2 g Powder for Sterile Concentrate | 2026-02-25 | 2026-08-17 | Manufacturing delay (Multiple countries) Alternatives: No authorised alternative listed. | register ↗ |
| 🇮🇹 Italy | Shortage HOLOXAN | 2025-12-16 | 2027-03-31 | Elevata richiesta/problemi produttivi: distribuzione contingentata Alternatives: AIFA: import of a foreign equivalent can be authorised. | register ↗ |
| 🇸🇪 Sweden | Shortage Holoxan Pulver till injektions-/infusionsvätska, lösning | 2026-01-31 | 2026-12-31 | — Alternatives: Alternative(s) available — see the national register. | register ↗ |
Every individual register entry for Ifosfamide in the tracked sources, newest first — including resolved and discontinued reports.
| Reg. | Product | Status | Reported | Expected end | Stated reason |
|---|---|---|---|---|---|
| 🇩🇪 DE | IFO-cell 5 g Konzentrat zur Herstellung einer Infusionslösung | Shortage | 2026-08-17 | 2027-12-31 | Probleme in der Herstellung |
| 🇩🇪 DE | IFO-cell N 1000 | Shortage | 2026-08-17 | 2027-12-31 | Probleme in der Herstellung |
| 🇩🇪 DE | IFO-cell N 2000 | Shortage | 2026-08-17 | 2027-12-31 | Probleme in der Herstellung |
| 🇩🇪 DE | IFO-cell 2g Konzentrat zur Herstellung einer Infusionslösung | Shortage | 2026-08-03 | 2027-12-31 | Probleme in der Herstellung |
| 🇮🇪 IE | Mitoxana 2 g Powder for Sterile Concentrate | Shortage | 2026-04-17 | 2026-08-17 | Manufacturing delay (Global) |
| 🇮🇪 IE | Mitoxana 1 g Powder for Sterile Concentrate | Shortage | 2026-02-25 | 2026-07-24 | Manufacturing delay (Multiple countries) |
| 🇪🇺 EU | Ifosfamide | Shortage | 2026-02-12 | — | Cancer |
| 🇸🇪 SE | Holoxan Pulver till injektions-/infusionsvätska, lösning | Shortage | 2026-01-31 | 2026-12-31 | |
| 🇦🇹 AT | Holoxan 1 g - Trockensubstanz zur Injektionsbereitung | Limited availability | 2026-01-26 | — | |
| 🇦🇹 AT | Holoxan 2 g - Trockensubstanz zur Injektionsbereitung | Limited availability | 2026-01-26 | — | |
| 🇩🇪 DE | Holoxan | Shortage | 2026-01-21 | 2026-12-31 | Probleme in der Herstellung |
| 🇮🇹 IT | HOLOXAN | Shortage | 2025-12-16 | 2027-03-31 | Elevata richiesta/problemi produttivi: distribuzione conting |
| 🇫🇷 FR | Holoxan 1000 mg, poudre pour solution injectable et 2000 mg, poudre po | Limited availability | — | — | Hématologie, Oncologie/Radiothérapie |
Yes. As of 8 September 2026, availability issues are reported in: Austria, Germany, EU-wide (EMA), France, Ireland, Italy, Sweden. Availability is national — a shortage in one country does not mean it is short everywhere.
Agency prognoses on file range from 2026-12-31 to 2027-12-31. These are manufacturer-reported estimates and frequently move; check the linked register entry for the latest date.
9 of the active register entries indicate alternatives or equivalents (same active substance or an alternative treatment). Do not switch on your own — a pharmacist or prescriber can confirm the right substitute in your country.
Directly from the official medicines-agency registers that list Ifosfamide: BASG (Austria), BfArM (Germany), EMA shortages catalogue (EU), ANSM (France), HPRA (Ireland), AIFA (Italy), Läkemedelsverket (Sweden). Every row on this page links to the underlying official record, and the dataset is refreshed from the primary sources every morning. Cross-language matching groups the same active substance across registers, so national spellings all resolve to this page.
Pharmacies, patient sites and newsrooms are welcome to embed the live status of Ifosfamide — free, with attribution. Copy this snippet:
<iframe src="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/ifosfamide/embed.html" width="100%" height="150" loading="lazy" style="border:1px solid #e1e0d9;border-radius:12px" title="Ifosfamide availability in Europe"></iframe> <p style="font-size:12px">Source: <a href="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/ifosfamide/">Ifosfamide shortage status — European Medicine Shortage Tracker</a> by MobiDoctor</p>