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Estradiol currently has availability issues reported in 3 European registers: Ireland, Italy, Sweden.
Shortage ATC — · also listed as: Estradiol · ESTRADIOLO · estradiolhemihydrat · data refreshed 9 September 2026
As of 9 September 2026, 3 of the 9 tracked registers list current availability issues for Estradiol, covering 14 affected product presentations. The longest-running open report was filed in Sweden on 2026-01-30 and has now been open for about 8 months. Where agencies state a cause, manufacturing problems lead with 2 of the 2 stated-cause reports. The furthest expected-resolution date currently on file is 2027-03-31; the earliest is 2026-10-01. Notably, 6 reports have already passed the expected-resolution date without closing — prognoses for this medicine should be read as estimates, not commitments. Momentum is current, not historical: 5 of the open reports were filed within the last 90 days. The issue spread across registers over time rather than at once: Sweden reported first (2026-01-30), with Italy following roughly 8 months later — a pattern typical of supply problems cascading between national markets. Registers in Ireland, Italy, Sweden indicate that alternatives or equivalents are available — a pharmacist or doctor can advise on switching.
| Where | Status & products | Since | Expected end | Reason / alternatives | Source |
|---|---|---|---|---|---|
| 🇮🇪 Ireland | Shortage Estradot 100 micrograms / 24 hours, transdermal patch + 3 more productsEstradot 37.5 micrograms / 24 hours, transdermal patch Estradot 50 micrograms / 24 hours, transdermal patch Estradot 75 micrograms / 24 hours, transdermal patch | 2026-04-28 | — | Manufacturing delay Alternatives: Alternative(s) available — see the national register. | register ↗ |
| 🇮🇹 Italy | Shortage LENZETTO | 2026-09-01 | 2027-03-31 | Elevata richiesta/problemi produttivi Alternatives: AIFA: an alternative treatment is available (ask your doctor). | register ↗ |
| 🇸🇪 Sweden | Shortage Divigel 0,5 mg Gel + 8 more productsDivigel 1 mg Gel Estradot 100 mikrogram/24 timmar Depotplåster Estradot 25 mikrogram/24 timmar Depotplåster Estradot 37,5 mikrogram/24 timmar Depotplåster Estradot 50 mikrogram/24 timmar Depotplåster Estradot 75 mikrogram/24 timmar Depotplåster Estrogel 0,75 mg/dos Transdermal gel Lenzetto 1,53 mg/sprayning Transdermal spray, lösning | 2026-01-30 | 2026-12-31 | — Alternatives: Alternative(s) available — see the national register. | register ↗ |
Every individual register entry for Estradiol in the tracked sources, newest first — including resolved and discontinued reports.
| Reg. | Product | Status | Reported | Expected end | Stated reason |
|---|---|---|---|---|---|
| 🇮🇹 IT | LENZETTO | Shortage | 2026-09-01 | 2027-03-31 | Elevata richiesta/problemi produttivi |
| 🇮🇪 IE | Estradot 100 micrograms / 24 hours, transdermal patch | Shortage | 2026-07-17 | — | |
| 🇮🇪 IE | Estradot 37.5 micrograms / 24 hours, transdermal patch | Shortage | 2026-07-17 | — | |
| 🇮🇪 IE | Estradot 50 micrograms / 24 hours, transdermal patch | Shortage | 2026-07-17 | — | |
| 🇸🇪 SE | Estradot 100 mikrogram/24 timmar Depotplåster | Shortage | 2026-06-17 | 2026-10-21 | |
| 🇸🇪 SE | Divigel 0,5 mg Gel | Shortage | 2026-06-01 | 2026-08-31 | |
| 🇸🇪 SE | Divigel 1 mg Gel | Shortage | 2026-06-01 | 2026-08-31 | |
| 🇸🇪 SE | Estrogel 0,75 mg/dos Transdermal gel | Shortage | 2026-05-07 | 2026-08-31 | |
| 🇮🇪 IE | Estradot 75 micrograms / 24 hours, transdermal patch | Shortage | 2026-04-28 | — | Manufacturing delay |
| 🇸🇪 SE | Estradot 37,5 mikrogram/24 timmar Depotplåster | Shortage | 2026-04-17 | 2026-10-01 | |
| 🇸🇪 SE | Estradot 25 mikrogram/24 timmar Depotplåster | Shortage | 2026-04-13 | 2026-07-29 | |
| 🇸🇪 SE | Estradot 75 mikrogram/24 timmar Depotplåster | Shortage | 2026-04-10 | 2026-08-28 | |
| 🇸🇪 SE | Lenzetto 1,53 mg/sprayning Transdermal spray, lösning | Shortage | 2026-03-17 | 2026-12-31 | |
| 🇸🇪 SE | Estradot 50 mikrogram/24 timmar Depotplåster | Shortage | 2026-01-30 | 2026-08-04 |
Yes. As of 9 September 2026, availability issues are reported in: Ireland, Italy, Sweden. Availability is national — a shortage in one country does not mean it is short everywhere.
Agency prognoses on file range from 2026-10-01 to 2027-03-31. These are manufacturer-reported estimates and frequently move; check the linked register entry for the latest date.
14 of the active register entries indicate alternatives or equivalents (same active substance or an alternative treatment). Do not switch on your own — a pharmacist or prescriber can confirm the right substitute in your country.
Directly from the official medicines-agency registers that list Estradiol: HPRA (Ireland), AIFA (Italy), Läkemedelsverket (Sweden). Every row on this page links to the underlying official record, and the dataset is refreshed from the primary sources every morning. Cross-language matching groups the same active substance across registers, so national spellings all resolve to this page.
Pharmacies, patient sites and newsrooms are welcome to embed the live status of Estradiol — free, with attribution. Copy this snippet:
<iframe src="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/estradiol/embed.html" width="100%" height="150" loading="lazy" style="border:1px solid #e1e0d9;border-radius:12px" title="Estradiol availability in Europe"></iframe> <p style="font-size:12px">Source: <a href="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/estradiol/">Estradiol shortage status — European Medicine Shortage Tracker</a> by MobiDoctor</p>