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Cyclophosphamide currently has availability issues reported in 6 European registers: Austria, Germany, Spain, EU-wide, France, Italy.
Shortage ATC L01AA01 · also listed as: CYCLOPHOSPHAMID · Cyclophosphamid Monohydrat · CICLOFOSFAMIDA · cyclophosphamide · CICLOFOSFAMIDE · data refreshed 10 September 2026
As of 10 September 2026, 6 of the 9 tracked registers list current availability issues for Cyclophosphamide, covering 16 affected product presentations. The longest-running open report was filed in Austria on 2025-10-14 and has now been open for about 11 months. Where agencies state a cause, manufacturing problems lead with 5 of the 8 stated-cause reports, followed by active-ingredient (API) supply issues with 2. The furthest expected-resolution date currently on file is 2028-01-03; the earliest is 2026-09-16. The issue spread across registers over time rather than at once: Austria reported first (2025-10-14), with the EMA catalogue following roughly 4 months later — a pattern typical of supply problems cascading between national markets. Registers in Germany, Spain, Italy indicate that alternatives or equivalents are available — a pharmacist or doctor can advise on switching. In the WHO ATC classification, Cyclophosphamide is coded L01AA01 — a medicine acting on antineoplastic and immunomodulating agents — so clinically related products appear under “Related medicines” below.
| Where | Status & products | Since | Expected end | Reason / alternatives | Source |
|---|---|---|---|---|---|
| 🇪🇺 EU-wide (EMA) | Shortage Cyclophosphamide | 2026-02-24 | — | Cancer | register ↗ |
| 🇦🇹 Austria | Shortage Cyclophosphamid Sandoz 1000 mg – Pulver zur Herstellung einer Injektions-/Infusionslösung + 4 more productsCyclophosphamid Sandoz 2000 mg – Pulver zur Herstellung einer Injektions-/Infusionslösung Endoxan "Baxter" 1 g - Trockenstechampulle Endoxan "Baxter" 200 mg - Trockenstechampulle Endoxan "Baxter" 500 mg - Trockenstechampulle | 2025-10-14 | — | — | register ↗ |
| 🇩🇪 Germany | Shortage Cyclophosphamid HEXAL 500 mg + 3 more productsEndoxan 1 g Endoxan 200 mg Endoxan 500 mg | 2026-01-21 | 2026-12-31 | Erhöhte Nachfrage Alternatives: N/A | register ↗ |
| 🇪🇸 Spain | Shortage CICLOFOSFAMIDA DR. REDDYS 500 MG/ML CONCENTRADO PARA SOLUCION INYECTABLE Y PARA PERFUSION, 1 vial de 1 ml + 1 more productsCICLOFOSFAMIDA SEACROSS 1.000 MG POLVO PARA SOLUCION INYECTABLE Y PARA PERFUSION EFG, 1 vial | 2026-02-01 | 2028-01-03 | Existen otros medicamentos con el mismo principio activo y misma vía. Alternatives: Existe/n otro/s medicamento/s con el mismo principio activo y para la misma vía de administración. | register ↗ |
| 🇫🇷 France | Limited availability Endoxan 50 mg, comprimé enrobé + 1 more productsEndoxan 500 et 1000 mg, poudre pour solution injectable | — | — | Oncologie/Radiothérapie, Rhumatologie | register ↗ |
| 🇮🇹 Italy | Shortage ENDOXAN BAXTER + 1 more productsENDOXAN BAXTER | 2025-12-23 | 2026-09-30 | Elevata richiesta/problemi produttivi: distribuzione contingentata Alternatives: AIFA: import of a foreign equivalent can be authorised. | register ↗ |
Every individual register entry for Cyclophosphamide in the tracked sources, newest first — including resolved and discontinued reports.
| Reg. | Product | Status | Reported | Expected end | Stated reason |
|---|---|---|---|---|---|
| 🇮🇹 IT | ENDOXAN BAXTER | Shortage | 2026-08-17 | — | Problemi produttivi |
| 🇩🇪 DE | Cyclophosphamid HEXAL 500 mg | Shortage | 2026-04-23 | 2026-09-16 | Erhöhte Nachfrage |
| 🇦🇹 AT | Endoxan "Baxter" 1 g - Trockenstechampulle | Limited availability | 2026-02-25 | — | |
| 🇦🇹 AT | Endoxan "Baxter" 200 mg - Trockenstechampulle | Limited availability | 2026-02-25 | — | |
| 🇦🇹 AT | Endoxan "Baxter" 500 mg - Trockenstechampulle | Limited availability | 2026-02-25 | — | |
| 🇪🇺 EU | Cyclophosphamide | Shortage | 2026-02-24 | — | Cancer |
| 🇪🇸 ES | CICLOFOSFAMIDA DR. REDDYS 500 MG/ML CONCENTRADO PARA SOLUCION INYECTAB | Shortage | 2026-02-09 | 2028-01-03 | |
| 🇪🇸 ES | CICLOFOSFAMIDA SEACROSS 1.000 MG POLVO PARA SOLUCION INYECTABLE Y PARA | Shortage | 2026-02-01 | — | Existen otros medicamentos con el mismo principio activo y m |
| 🇩🇪 DE | Endoxan 1 g | Shortage | 2026-01-21 | 2026-12-31 | Probleme in der Herstellung |
| 🇩🇪 DE | Endoxan 200 mg | Shortage | 2026-01-21 | 2026-12-31 | Probleme in der Herstellung |
| 🇩🇪 DE | Endoxan 500 mg | Shortage | 2026-01-21 | 2026-12-31 | Probleme in der Herstellung |
| 🇮🇹 IT | ENDOXAN BAXTER | Shortage | 2025-12-23 | 2026-09-30 | Elevata richiesta/problemi produttivi: distribuzione conting |
| 🇦🇹 AT | Cyclophosphamid Sandoz 1000 mg – Pulver zur Herstellung einer Injektio | Shortage | 2025-10-14 | — | |
| 🇦🇹 AT | Cyclophosphamid Sandoz 2000 mg – Pulver zur Herstellung einer Injektio | Shortage | 2025-10-14 | — | |
| 🇫🇷 FR | Endoxan 50 mg, comprimé enrobé | Limited availability | — | — | Oncologie/Radiothérapie, Rhumatologie |
| 🇫🇷 FR | Endoxan 500 et 1000 mg, poudre pour solution injectable | Limited availability | — | — | Oncologie/Radiothérapie |
Yes. As of 10 September 2026, availability issues are reported in: Austria, Germany, Spain, EU-wide (EMA), France, Italy. Availability is national — a shortage in one country does not mean it is short everywhere.
Agency prognoses on file range from 2026-09-16 to 2028-01-03. These are manufacturer-reported estimates and frequently move; check the linked register entry for the latest date.
7 of the active register entries indicate alternatives or equivalents (same active substance or an alternative treatment). Do not switch on your own — a pharmacist or prescriber can confirm the right substitute in your country.
Directly from the official medicines-agency registers that list Cyclophosphamide: BASG (Austria), BfArM (Germany), AEMPS CIMA (Spain), EMA shortages catalogue (EU), ANSM (France), AIFA (Italy). Every row on this page links to the underlying official record, and the dataset is refreshed from the primary sources every morning. Cross-language matching groups the same active substance across registers, so national spellings all resolve to this page.
Pharmacies, patient sites and newsrooms are welcome to embed the live status of Cyclophosphamide — free, with attribution. Copy this snippet:
<iframe src="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/cyclophosphamide/embed.html" width="100%" height="150" loading="lazy" style="border:1px solid #e1e0d9;border-radius:12px" title="Cyclophosphamide availability in Europe"></iframe> <p style="font-size:12px">Source: <a href="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/cyclophosphamide/">Cyclophosphamide shortage status — European Medicine Shortage Tracker</a> by MobiDoctor</p>