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Aprepitant currently has availability issues reported in 6 European registers: Austria, Germany, Spain, France, Ireland, Italy.
Shortage ATC A04AD12 · also listed as: APREPITANT · aprépitant · Aprepitant, Aprepitant · APREPITANT + APREPITANT · data refreshed 12 September 2026
As of 12 September 2026, 6 of the 9 tracked registers list current availability issues for Aprepitant, covering 19 affected product presentations. The longest-running open report was filed in Italy on 2020-12-15 and has now been open for about 69 months. Where agencies state a cause, manufacturing problems lead with 6 of the 12 stated-cause reports, followed by unexpectedly high demand with 3. The furthest expected-resolution date currently on file is 2027-07-30; the earliest is 2026-09-17. Momentum is current, not historical: 2 of the open reports were filed within the last 90 days. The issue spread across registers over time rather than at once: Italy reported first (2020-12-15), with Austria following roughly 62 months later — a pattern typical of supply problems cascading between national markets. Registers in Germany, Spain, Ireland, Italy indicate that alternatives or equivalents are available — a pharmacist or doctor can advise on switching. In the WHO ATC classification, Aprepitant is coded A04AD12 — a medicine acting on alimentary tract and metabolism — so clinically related products appear under “Related medicines” below.
| Where | Status & products | Since | Expected end | Reason / alternatives | Source |
|---|---|---|---|---|---|
| 🇪🇺 EU-wide (EMA) | Resolved Emend (aprepitant) | 2024-04-12 | — | Vomiting;Postoperative Nausea and Vomiting;Cancer;Neoplasms | register ↗ |
| 🇦🇹 Austria | Shortage Aprepitant Accord 125 mg Hartkapseln + 3 more productsAprepitant Accord 80 mg Hartkapseln Aprepitant Sandoz 80 mg – Hartkapseln Aprepitant ratiopharm 125 mg Hartkapseln | 2026-02-04 | — | — | register ↗ |
| 🇩🇪 Germany | Shortage Aprepitant AL 125 mg Hartkapseln + 6 more productsAprepitant AL 125 mg und 80 mg Hartkapseln Aprepitant AL 80 mg Hartkapseln Aprepitant STADA 125 mg Hartkapseln Aprepitant STADA 125 mg und 80 mg Hartkapseln Aprepitant Zentiva 80 mg und 125 mg Hartkapseln Aprepitant beta 80 mg Hartkapseln | 2024-08-01 | 2026-12-30 | Erhöhte Nachfrage Alternatives: N/A | register ↗ |
| 🇪🇸 Spain | Shortage APREPITANT ACCORD 125 MG CAPSULAS DURAS EFG/APREPITANT ACCORD 80 MG CAPSULAS DURAS EFG, 1 cápsula de 125 mg + 2 cápsulas de 80 mg + 1 more productsAPREPITANT SANDOZ 125 MG CAPSULAS DURAS EFG/APREPITANT SANDOZ 80 MG CAPSULAS DURAS EFG, 1 cápsula de 125 mg y 2 cápsulas de 80 mg | 2024-07-10 | 2027-07-30 | Se puede solicitar como medicamento extranjero. Alternatives: Se puede solicitar como medicamento extranjero. | register ↗ |
| 🇫🇷 France | Limited availability Emend 125 mg, poudre pour suspension buvable + 1 more productsSpécialités à base d'aprépitant 125 mg, 80 mg et 125 mg/80 mg gélules | — | — | Hépato-gastroentérologie | register ↗ |
| 🇮🇪 Ireland | Shortage Aprepitant Accord 125 mg / 80 mg hard capsules + 2 more productsAprepitant Accord 125 mg hard capsules Aprepitant Accord 80 mg hard capsules | 2024-09-01 | 2027-02-01 | Manufacturing delay Alternatives: Alternative(s) available — see the national register. | register ↗ |
| 🇮🇹 Italy | Shortage APREPITANT ACCORD + 3 more productsATANTO EMEND EMEND | 2020-12-15 | — | Problemi produttivi Alternatives: AIFA: import of a foreign equivalent can be authorised. | register ↗ |
Every individual register entry for Aprepitant in the tracked sources, newest first — including resolved and discontinued reports.
| Reg. | Product | Status | Reported | Expected end | Stated reason |
|---|---|---|---|---|---|
| 🇮🇹 IT | EMEND | Shortage | 2026-11-30 | — | Cessata commercializzazione definitiva |
| 🇪🇸 ES | APREPITANT SANDOZ 125 MG CAPSULAS DURAS EFG/APREPITANT SANDOZ 80 MG CA | Shortage | 2026-08-16 | 2026-09-17 | Se puede solicitar como medicamento extranjero. |
| 🇦🇹 AT | Aprepitant ratiopharm 125 mg Hartkapseln | Resolved | 2026-06-17 | — | |
| 🇦🇹 AT | Aprepitant Sandoz 80 mg – Hartkapseln | Limited availability | 2026-05-11 | — | |
| 🇮🇹 IT | ATANTO | Shortage | 2026-05-05 | — | Cessata commercializzazione temporanea |
| 🇦🇹 AT | Aprepitant Accord 125 mg Hartkapseln | Shortage | 2026-02-04 | — | |
| 🇦🇹 AT | Aprepitant Accord 80 mg Hartkapseln | Limited availability | 2026-02-04 | — | |
| 🇮🇪 IE | Aprepitant Accord 125 mg hard capsules | Shortage | 2026-02-03 | 2027-02-01 | Manufacturing delay |
| 🇩🇪 DE | Aprepitant Zentiva 80 mg und 125 mg Hartkapseln | Shortage | 2025-10-01 | 2026-10-21 | Probleme in der Herstellung |
| 🇩🇪 DE | Aprepitant AL 125 mg und 80 mg Hartkapseln | Shortage | 2025-09-01 | 2026-10-01 | Erhöhte Nachfrage |
| 🇮🇪 IE | Aprepitant Accord 80 mg hard capsules | Shortage | 2025-05-12 | 2027-02-01 | Manufacturing delay (Multiple countries) |
| 🇩🇪 DE | Aprepitant STADA 125 mg Hartkapseln | Resolved | 2025-02-17 | 2026-08-31 | Probleme in der Herstellung |
| 🇩🇪 DE | Aprepitant beta 80 mg Hartkapseln | Shortage | 2025-02-10 | 2026-12-30 | Probleme in der Herstellung |
| 🇩🇪 DE | Aprepitant AL 80 mg Hartkapseln | Shortage | 2024-11-01 | 2026-10-01 | Erhöhte Nachfrage |
| 🇮🇪 IE | Aprepitant Accord 125 mg / 80 mg hard capsules | Shortage | 2024-09-01 | 2027-02-01 | Manufacturing delay |
| 🇩🇪 DE | Aprepitant STADA 125 mg und 80 mg Hartkapseln | Resolved | 2024-08-05 | 2026-08-31 | Probleme in der Herstellung |
| 🇩🇪 DE | Aprepitant AL 125 mg Hartkapseln | Shortage | 2024-08-01 | 2026-10-01 | Erhöhte Nachfrage |
| 🇪🇸 ES | APREPITANT ACCORD 125 MG CAPSULAS DURAS EFG/APREPITANT ACCORD 80 MG CA | Shortage | 2024-07-10 | 2027-07-30 | Se puede solicitar como medicamento extranjero. |
| 🇪🇺 EU | Emend (aprepitant) | Resolved | 2024-04-12 | — | Vomiting;Postoperative Nausea and Vomiting;Cancer;Neoplasms |
| 🇮🇹 IT | APREPITANT ACCORD | Shortage | 2024-01-15 | — | Problemi produttivi |
| 🇮🇹 IT | EMEND | Shortage | 2020-12-15 | — | Cessata commercializzazione definitiva |
| 🇫🇷 FR | Emend 125 mg, poudre pour suspension buvable | Limited availability | — | — | Hépato-gastroentérologie |
| 🇫🇷 FR | Spécialités à base d'aprépitant 125 mg, 80 mg et 125 mg/80 mg gélules | Limited availability | — | — | Hépato-gastroentérologie |
Yes. As of 12 September 2026, availability issues are reported in: Austria, Germany, Spain, France, Ireland, Italy. Availability is national — a shortage in one country does not mean it is short everywhere.
Agency prognoses on file range from 2026-09-17 to 2027-07-30. These are manufacturer-reported estimates and frequently move; check the linked register entry for the latest date.
14 of the active register entries indicate alternatives or equivalents (same active substance or an alternative treatment). Do not switch on your own — a pharmacist or prescriber can confirm the right substitute in your country.
Directly from the official medicines-agency registers that list Aprepitant: BASG (Austria), BfArM (Germany), AEMPS CIMA (Spain), EMA shortages catalogue (EU), ANSM (France), HPRA (Ireland), AIFA (Italy). Every row on this page links to the underlying official record, and the dataset is refreshed from the primary sources every morning. Cross-language matching groups the same active substance across registers, so national spellings all resolve to this page.
Pharmacies, patient sites and newsrooms are welcome to embed the live status of Aprepitant — free, with attribution. Copy this snippet:
<iframe src="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/aprepitant/embed.html" width="100%" height="150" loading="lazy" style="border:1px solid #e1e0d9;border-radius:12px" title="Aprepitant availability in Europe"></iframe> <p style="font-size:12px">Source: <a href="https://www.mobidoctor.eu/medicine-shortages/medicine-shortages/aprepitant/">Aprepitant shortage status — European Medicine Shortage Tracker</a> by MobiDoctor</p>